which drug goes through extensive first pass hepatic metabolism

ATI RN

Proctored Pharmacology ATI

1. Which drug undergoes extensive first-pass hepatic metabolism?

A. Heparin
B. Insulin
C. Propranolol
D. Nitroglycerin

Correct answer: C

Rationale: Propranolol undergoes extensive first-pass hepatic metabolism in the liver. When administered orally, propranolol is extensively metabolized by the liver before reaching systemic circulation, leading to reduced bioavailability. This process is known as first-pass hepatic metabolism, which significantly affects the drug's effectiveness and necessitates higher oral doses compared to other routes of administration. Heparin (Choice A) is not metabolized by the liver but excreted unchanged by the kidneys. Insulin (Choice B) is a peptide hormone that is not subject to significant first-pass metabolism. Nitroglycerin (Choice D) is primarily metabolized in the blood and tissues, bypassing significant first-pass metabolism in the liver.

2. What is levothyroxine's pharmacologic classification?

A. Thyroid Preparations
B. Metabolic Inhibitors
C. Analgesic
D. Loop Diuretic

Correct answer: A

Rationale: Levothyroxine is classified as a thyroid preparation because it is a synthetic form of the thyroid hormone thyroxine. It is primarily used to treat hypothyroidism by supplementing or replacing the natural thyroid hormones in the body, helping to regulate metabolism and energy levels. Choice B, Metabolic Inhibitors, is incorrect because levothyroxine does not inhibit metabolism but rather helps regulate it. Choice C, Analgesic, is incorrect as levothyroxine is not used for pain relief but for thyroid hormone replacement therapy. Choice D, Loop Diuretic, is also incorrect as loop diuretics are medications that act on the kidneys to increase urine production and are not related to thyroid hormone replacement therapy.

3. A client has a new prescription for Digoxin to treat heart failure. Which of the following instructions should the nurse include in the teaching?

A. Contact the provider if the heart rate is less than 60/min.
B. Check the pulse rate for 30 seconds and multiply the result by 2.
C. Increase the intake of sodium.
D. Take with food if nausea occurs.

Correct answer: A

Rationale: The correct answer is A. It is crucial for clients on Digoxin to monitor their heart rate. A heart rate less than 60/min can indicate bradycardia, a potential side effect of Digoxin. Therefore, the client should be instructed to contact the provider if their heart rate is less than 60/min to prevent complications and receive appropriate management. Choices B, C, and D are incorrect. Checking the pulse rate for 30 seconds and multiplying by 2 is not specific to Digoxin administration. Increasing sodium intake is contraindicated as Digoxin can lead to sodium retention. Taking Digoxin with food if nausea occurs is not recommended as it may affect the drug's absorption.

4. A client has a new prescription for Digoxin to treat heart failure. Which of the following findings should the nurse monitor as an adverse effect?

A. Visual disturbances
B. Dry cough
C. Confusion
D. Urinary retention

Correct answer: A

Rationale: Visual disturbances, such as blurred or yellow vision, can be an early sign of digoxin toxicity. Monitoring for visual changes is crucial to detect and prevent potential adverse effects of digoxin. Dry cough, confusion, and urinary retention are not commonly associated adverse effects of digoxin and are not typically monitored in relation to this medication.

5. When should a blood sample be obtained for a peak serum level of gentamicin when administered by IV infusion for 1 hour at 0900?

A. 1000
B. 1030
C. 1100
D. 1130

Correct answer: B

Rationale: The nurse should obtain the blood sample for the peak serum level at 1030. This timing allows for 30 minutes to elapse after the completion of the 1-hour IV infusion, which is the recommended window for obtaining the peak serum level of gentamicin.