when the body produces antibodies against its own tissue the condition is called

ATI RN

ATI Pathophysiology

1. When the body produces antibodies against its own tissue, the condition is called

A. Alloimmunity
B. Opsonization
C. Autoimmunity
D. Hypersensitivity

Correct answer: C

Rationale: The correct answer is C, autoimmunity. Autoimmunity refers to the immune system attacking the body's own tissues. Alloimmunity (choice A) is the immune response to tissues of another individual of the same species. Opsonization (choice B) is the process where pathogens are marked for destruction by immune cells. Hypersensitivity (choice D) refers to excessive or inappropriate immune responses.

2. A patient has been diagnosed with a fungal infection and is to be treated with itraconazole (Sporanox). Prior to administration, the nurse notes that the patient is taking carbamazepine (Tegretol) for a seizure disorder. Based on this medication regime, which of the following will be true regarding the medications?

A. The serum level of carbamazepine will be increased.
B. The patient's carbamazepine should be discontinued.
C. The patient's antiseizure medication should be changed.
D. The patient will require a higher dosage of itraconazole (Sporanox).

Correct answer: A

Rationale: When itraconazole is administered with carbamazepine, itraconazole may increase the serum levels of carbamazepine, potentially leading to toxicity. Therefore, choice A is correct. Discontinuing carbamazepine (choice B) or changing the antiseizure medication (choice C) is not necessary unless advised by a healthcare provider. Choice D, requiring a higher dosage of itraconazole, is not accurate in this scenario.

3. In which patient would the manifestation of a headache be a sign of a serious underlying disorder?

A. A 55-year-old man with new onset of headaches that are worse at night and reported mood swings according to his family
B. A 30-year-old woman with a unilateral throbbing headache with photophobia and nausea
C. A 60-year-old man with his head feeling full and throbbing and muscle aching around his neck and shoulders
D. A 40-year-old woman who experiences food cravings, gets irritable, and then develops a pulsatile-like headache on the right side of her head

Correct answer: A

Rationale: The correct answer is A. New onset headaches in older adults, especially if worse at night, may indicate a serious condition like a brain tumor. Choice B describes symptoms commonly seen in migraines. Choice C describes tension-type headaches. Choice D describes symptoms of a menstrual migraine which is not typically associated with a serious underlying disorder.

4. A toddler is displaying signs/symptoms of weakness and muscle atrophy. The pediatric neurologist suspects it may be a lower motor neuron disease called spinal muscular atrophy (SMA). The client's family asks how he got this. The nurse will respond:

A. This could result from playing in soil and then ingesting bacteria that is now attacking his motor neurons.
B. No one really knows how this disease is formed. We just know that in time, he may grow out of it.
C. This is a degenerative disorder that tends to be inherited as an autosomal recessive trait.
D. This is a segmental demyelination disorder that affects all nerve roots and eventually all muscle groups as well.

Correct answer: C

Rationale: The correct answer is C. Spinal muscular atrophy (SMA) is an inherited disorder, often autosomal recessive, that affects lower motor neurons. Choice A is incorrect because SMA is not caused by ingesting bacteria from playing in soil. Choice B is incorrect as SMA is not something that a person grows out of. Choice D is incorrect because SMA is not a demyelination disorder that affects nerve roots and muscle groups.

5. What are the major mechanisms of spinal cord injuries?

A. Hypoextension, expansion, hyperflexion
B. Hyperflexion, expansion, hypometabolism
C. Hypermetabolism, compression, hyperextension
D. Hyperextension, hyperflexion, compression

Correct answer: D

Rationale: The correct answer is D. Spinal cord injuries commonly occur due to hyperextension, hyperflexion, and compression. Hyperextension and hyperflexion refer to the excessive bending or stretching of the spinal cord, while compression is the exertion of pressure on the spinal cord. These mechanisms can lead to damage such as contusions, lacerations, and compression of the spinal cord. Choices A, B, and C are incorrect as they do not accurately represent the major mechanisms of spinal cord injuries.