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MSN 570 Advanced Pathophysiology Final 2024
1. The early stages of atheroma development are characterized by:
- A. macrophages full of oxidized low-density lipoprotein (LDL; i.e., foam cells) in the intima
- B. accumulation of lipids in the intima (i.e., fatty streak)
- C. accumulation of proteins such as collagen and elastin (i.e., fibrous cap)
- D. development of calcium and a necrotic lipid core
Correct answer: A
Rationale: The correct answer is A. In the early stages of atheroma development, macrophages accumulate oxidized low-density lipoprotein (LDL) and transform into foam cells, leading to the formation of fatty streaks in the intima of blood vessels. This process is a hallmark of the initial stages of atherosclerosis. Choice B is incorrect as it describes the accumulation of lipids in the intima, which is a later event following foam cell formation. Choice C is also incorrect as it refers to the accumulation of proteins forming the fibrous cap, which occurs at a later stage to stabilize the atheroma. Choice D is incorrect as it describes the development of calcium and a necrotic lipid core, typically seen in advanced atherosclerosis rather than the early stages.
2. A patient taking oral contraceptives reports breakthrough bleeding. What should the nurse assess in this patient?
- A. Adherence to the medication schedule
- B. The possibility of pregnancy
- C. The need for an increased dosage
- D. The effectiveness of the current oral contraceptive
Correct answer: A
Rationale: When a patient on oral contraceptives experiences breakthrough bleeding, the nurse should assess the patient's adherence to the medication schedule. Breakthrough bleeding can be a sign of missed doses or inconsistent timing, which can decrease the effectiveness of oral contraceptives. Assessing the patient's adherence helps in ensuring proper use of the medication. Choices B, C, and D are incorrect because breakthrough bleeding is more likely related to adherence issues rather than pregnancy, the need for increased dosage, or the effectiveness of the current oral contraceptive.
3. An older adult patient comes to the clinic complaining of not being able to do what he used to be able to. You know that normal changes associated with aging include:
- A. Improved blood flow
- B. Slowed metabolic rate
- C. Increased brain weight
- D. Improved nerve fiber conduction
Correct answer: B
Rationale: Normal changes associated with aging include a slowed metabolic rate and decreased brain weight. Option A, 'Improved blood flow,' is incorrect as aging is generally associated with reduced vascular health rather than improved blood flow. Option D, 'Improved nerve fiber conduction,' is incorrect as aging typically leads to a decline in nerve function rather than improvement.
4. When arterial blood pressure declines, the kidneys secrete a hormone to increase blood pressure and peripheral resistance. What is this hormone called?
- A. Renin
- B. Antidiuretic hormone
- C. Atrial natriuretic
- D. Insulin
Correct answer: A
Rationale: Renin is the correct answer. When arterial blood pressure decreases, the kidneys release renin, which triggers a series of reactions ultimately leading to an increase in blood pressure and peripheral resistance. Antidiuretic hormone (choice B) is involved in water retention, atrial natriuretic hormone (choice C) promotes sodium excretion and lowers blood pressure, and insulin (choice D) regulates glucose metabolism, not blood pressure.
5. Which of the following describes the etiology of a cerebrovascular accident (CVA)?
- A. A blow to the head from a hard object
- B. Lack of blood flow to part of the brain
- C. Excessive exercise, such as running
- D. A ruptured artery in the heart
Correct answer: B
Rationale: The correct answer is B. A cerebrovascular accident (CVA), or stroke, is often caused by a lack of blood flow to part of the brain. This leads to damage in the brain tissue due to the deprived oxygen and nutrients. Choices A, C, and D are incorrect. A blow to the head from a hard object can cause a traumatic brain injury but is not the etiology of a CVA. Excessive exercise like running does not typically lead to a stroke. A ruptured artery in the heart may result in a heart attack, not a cerebrovascular accident.
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