ATI RN
ATI Proctored Pharmacology Test
1. A healthcare professional in a provider's clinic is caring for a client who reports erectile dysfunction and requests a prescription for sildenafil. Which of the following medications currently prescribed for the client is a contraindication to taking sildenafil?
- A. Isosorbide
- B. Phenytoin
- C. Metronidazole
- D. Prednisone
Correct answer: A
Rationale: Sildenafil is contraindicated with nitrates like isosorbide due to the risk of severe hypotension. Isosorbide is a nitrate that can potentiate the hypotensive effects of sildenafil, leading to a dangerous drop in blood pressure. Therefore, it is essential to avoid concurrent use of isosorbide and sildenafil to prevent adverse effects. Phenytoin, metronidazole, and prednisone do not have significant interactions with sildenafil and are not contraindicated when used together.
2. When reviewing facility policies for IV therapy with the team, a nurse manager should remind the team that which technique helps minimize the risk of catheter embolism?
- A. Performing hand hygiene before and after IV insertion
- B. Rotating IV sites at least every 72 hours
- C. Minimizing tourniquet time
- D. Avoiding reinserting the needle into an IV catheter
Correct answer: D
Rationale: Avoiding reinserting the needle into an IV catheter is crucial to minimizing the risk of catheter embolism. Reinserting the needle can lead to the severing of the catheter's end, potentially causing a catheter embolism, a serious complication. The other options, while important for IV therapy safety, are not directly related to preventing catheter embolism.
3. A client with Hodgkin's disease is receiving Cyclophosphamide IV. Which medication should be administered concurrently to prevent an adverse effect of Cyclophosphamide?
- A. Uroprotectant agent, such as mesna
- B. Opioid, such as morphine
- C. Loop diuretic, such as furosemide
- D. H1 receptor antagonist, such as diphenhydramine
Correct answer: A
Rationale: Mesna, an uroprotectant agent, is administered with nitrogen mustard chemotherapy drugs like Cyclophosphamide to prevent hemorrhagic cystitis, a common adverse effect. Mesna works by binding to and inactivating the toxic metabolites of Cyclophosphamide in the bladder, thereby reducing the risk of bladder toxicity.
4. A client has a new prescription for Clonidine. Which of the following adverse effects should the nurse monitor?
- A. Drowsiness
- B. Dry mouth
- C. Weight gain
- D. Insomnia
Correct answer: B
Rationale: Dry mouth is a common adverse effect of Clonidine. Clonidine can reduce saliva production, leading to dry mouth. To alleviate this symptom, the client should be advised to increase fluid intake or use sugar-free gum or candy. Monitoring for dry mouth is important to prevent complications such as oral health issues. Drowsiness, weight gain, and insomnia are potential side effects of Clonidine but are less common compared to dry mouth. Therefore, the nurse should prioritize monitoring for dry mouth as it's a more prevalent adverse effect associated with this medication.
5. What instruction should the healthcare provider include to minimize an adverse effect of Clomipramine for OCD in an adolescent client?
- A. Wear sunglasses when outdoors.
- B. Check your temperature daily.
- C. Take this medication in the morning.
- D. Add extra calories to your diet.
Correct answer: A
Rationale: The correct answer is A: 'Wear sunglasses when outdoors.' To minimize the anticholinergic effect of Clomipramine, the client should wear sunglasses when outdoors to reduce photophobia. This adverse effect is common with tricyclic antidepressant (TCA) use. Choices B, C, and D are incorrect. Checking temperature daily, timing of medication intake, or adding extra calories to the diet are not directly related to minimizing adverse effects of Clomipramine.
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