HESI A2
HESI A2 Biology 2024
1. Which is not a product of the Krebs cycle?
- A. ATP
- B. Carbon dioxide
- C. Glucose
- D. NADH
Correct answer: C
Rationale: Glucose is not a direct product of the Krebs cycle. Glucose is a starting molecule that undergoes glycolysis outside the mitochondria to produce pyruvate, which then enters the mitochondrial matrix to participate in the Krebs cycle. The Krebs cycle primarily generates ATP, carbon dioxide, and NADH as products. Choices A, B, and D are all products of the Krebs cycle, making them incorrect answers.
2. Which of the following structures is not directly involved in translation?
- A. tRNA
- B. mRNA
- C. ribosome
- D. DNA
Correct answer: D
Rationale: The correct answer is 'D: DNA.' DNA is not directly involved in translation, which is the process of synthesizing proteins from mRNA. tRNA carries amino acids to the ribosome, mRNA provides the template for protein synthesis, and ribosomes are the cellular machinery where translation occurs. DNA's main role is in transcription, where it serves as the template for mRNA synthesis, not in translation.
3. In an example of a male with hemophilia and a female carrier, what ratio of the offspring is predicted to have the disease?
- A. 0 female : 2 males
- B. 1 female : 0 males
- C. 1 female : 2 males
- D. 2 females : 1 male
Correct answer: C
Rationale: In this scenario, the male offspring will inherit the hemophilia trait from their mother due to the sex-linked inheritance pattern. The female offspring will inherit one X chromosome from their mother, becoming carriers of hemophilia. Therefore, the predicted ratio of offspring with the disease would be 1 female as a carrier and 2 males with hemophilia. Choice A is incorrect because there would be male offspring with the disease. Choice B is incorrect as there would be male offspring with hemophilia. Choice D is incorrect as it does not reflect the inheritance pattern of hemophilia.
4. The two catabolic pathways that lead to cellular energy production are:
- A. fermentation and protein synthesis
- B. cellular respiration and glycolysis
- C. fermentation and glycolysis
- D. cellular respiration and fermentation
Correct answer: D
Rationale: The correct answer is D: cellular respiration and fermentation. Cellular respiration involves the breakdown of glucose in the presence of oxygen to produce ATP, which is the primary source of energy for cells. Fermentation, on the other hand, occurs in the absence of oxygen and produces ATP through glycolysis followed by specific fermentation pathways. Choices A, B, and C are incorrect. Protein synthesis is a biosynthetic process, not a catabolic pathway for energy production. Glycolysis is a common step in both cellular respiration and fermentation, so it is not a pair of distinct catabolic pathways. Therefore, the most accurate pairing of catabolic pathways for cellular energy production is cellular respiration and fermentation.
5. Enzymes can _ reactions.
- A. Catalyze
- B. Inhibit
- C. Stop
- D. None of the above
Correct answer: A
Rationale: Enzymes function as catalysts that promote and accelerate chemical reactions in biological systems. They do this by lowering the activation energy required for the reactions to occur, thereby speeding up the process without being consumed in the reaction. Enzymes facilitate reactions rather than inhibiting or stopping them. Therefore, the correct answer is 'Catalyze.' 'Inhibit' and 'Stop' are incorrect because enzymes do not hinder or halt reactions but rather enhance them.
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