HESI A2
Biology HESI A2 2024
1. Physical factors such as temperature and pH can alter enzyme activity because they have an effect on the enzyme's ___________.
- A. acidity
- B. shape
- C. chemistry
- D. substrate
Correct answer: B
Rationale: Physical factors such as temperature and pH can alter enzyme activity by affecting the enzyme's shape. Enzymes rely on their specific shapes to function properly and catalyze reactions. Any changes in temperature or pH can disrupt these shapes, causing the enzyme to become denatured and lose its functionality. Therefore, alterations in temperature and pH can impact enzyme activity by directly affecting their shapes. Choices A, C, and D are incorrect because while pH can affect acidity and chemical properties of the enzyme, and temperature can influence the enzyme-substrate interaction, the primary reason for enzyme activity alteration due to temperature and pH is the change in the enzyme's shape.
2. What is represented by this formula: 6CO₂ + 6H₂O → C₆H₁₂O₆ + 6O₂?
- A. Glycolysis
- B. Cellular respiration
- C. Photosynthesis
- D. Electronic transport
Correct answer: C
Rationale: The formula represents the process of photosynthesis, where carbon dioxide (CO₂) and water (H₂O) are converted into glucose (C₆H₁₂O₆) and oxygen (O₂) using light energy. This process is essential for plants and some microorganisms to produce food and oxygen. Glycolysis and cellular respiration involve breaking down glucose to produce energy, and the electron transport chain is part of cellular respiration, not photosynthesis.
3. Imagine that two parents both carry the recessive gene for cystic fibrosis. Any homozygous recessive offspring will manifest the disease. What percentage of the offspring is predicted to be carriers but not manifest the disease?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: When both parents carry the recessive gene for cystic fibrosis (homozygous recessive), there is a 25% chance for each offspring to inherit two recessive alleles and, therefore, manifest the disease. There is also a 50% chance for each offspring to inherit one recessive allele and one dominant allele, making them carriers of the disease but not manifest it. Therefore, 25% of the offspring are predicted to be carriers but not manifest the disease. Choice A (0%) is incorrect because there is a portion of offspring that will be carriers. Choice C (50%) is incorrect as this percentage corresponds to carriers who will not manifest the disease. Choice D (100%) is incorrect as not all offspring will be carriers and not manifest the disease.
4. What takes place in a lysosome?
- A. Ribosomes are made.
- B. Food is produced.
- C. Water is stored.
- D. Food is digested.
Correct answer: D
Rationale: In a lysosome, food particles are digested through the action of enzymes. Lysosomes are membrane-bound organelles containing digestive enzymes that break down large molecules into smaller ones, allowing the cell to utilize the nutrients for energy and other processes. Choices A, B, and C are incorrect because ribosomes are not made in lysosomes, food is not produced in lysosomes, and lysosomes do not store water.
5. In an example of a male with hemophilia and a female carrier, what ratio of the offspring is predicted to have the disease?
- A. 0 female : 2 males
- B. 1 female : 0 males
- C. 1 female : 2 males
- D. 2 females : 1 male
Correct answer: C
Rationale: In this scenario, the male offspring will inherit the hemophilia trait from their mother due to the sex-linked inheritance pattern. The female offspring will inherit one X chromosome from their mother, becoming carriers of hemophilia. Therefore, the predicted ratio of offspring with the disease would be 1 female as a carrier and 2 males with hemophilia. Choice A is incorrect because there would be male offspring with the disease. Choice B is incorrect as there would be male offspring with hemophilia. Choice D is incorrect as it does not reflect the inheritance pattern of hemophilia.
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