huntingtons disease is carried on the dominant allele in a situation where two heterozygous parents have the disease what percentage of their offsprin
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HESI A2

HESI A2 Biology 2024

1. Huntington’s disease is carried on the dominant allele. In a situation where two heterozygous parents have the disease, what percentage of their offspring are predicted to be disease-free?

Correct answer: B

Rationale: In this scenario, both parents are heterozygous for Huntington's disease, meaning each carries one dominant allele (representing the disease) and one recessive allele (representing no disease). When they have offspring, there is a 25% chance that each child will inherit two recessive alleles, making them disease-free. The Punnett square for two heterozygous parents (Hh x Hh) yields a 25% probability of offspring being homozygous recessive (hh) and therefore disease-free. Choice A (0%) is incorrect because there is a possibility of disease-free offspring. Choice C (50%) is incorrect as it represents the likelihood of being a carrier. Choice D (100%) is incorrect as all offspring will not be disease-free in this scenario.

2. Which of the following is not true about enzymes?

Correct answer: B

Rationale: Enzymes lower the activation energy needed for a reaction to occur, not raise it. By lowering the activation energy, enzymes facilitate reactions, making them occur more easily and rapidly. Choice A is correct as enzymes indeed catalyze reactions. Choice C is correct as enzymes have specific active sites where substrates bind. Choice D is correct as enzymes are commonly proteins, although some RNA molecules also exhibit catalytic properties.

3. What process do cells in the tip of a plant’s root undergo to increase in number?

Correct answer: D

Rationale: Cells in the tip of a plant's root undergo the process of mitosis to increase in number. Mitosis is a type of cell division that results in two daughter cells with the same number of chromosomes as the parent cell. This process allows for growth and maintenance of tissues in plants by producing new cells through division. Choice A, Meiosis, is incorrect as meiosis is a type of cell division that reduces the number of chromosomes in cells to produce gametes. Choice B, Cytokinesis, is incorrect as it is the division of the cytoplasm following cell division. Choice C, Fractioning, is not a biological process related to cell division.

4. How many chromosomes do sperm and egg produce in meiosis?

Correct answer: B

Rationale: Sperm and egg cells undergo meiosis to form gametes with half the number of chromosomes found in somatic cells. Each sperm and egg cell produces 23 chromosomes through meiosis. Choice A is incorrect because 46 chromosomes represent the diploid number found in somatic cells. Choice C is incorrect as it is an uncommon number for chromosome production in human gametes. Choice D is incorrect as the total number of chromosomes in sperm or egg cells is 23, not 24.

5. Physical factors such as temperature and pH can alter enzyme activity because they have an effect on the enzyme's ___________.

Correct answer: B

Rationale: Physical factors such as temperature and pH can alter enzyme activity by affecting the enzyme's shape. Enzymes rely on their specific shapes to function properly and catalyze reactions. Any changes in temperature or pH can disrupt these shapes, causing the enzyme to become denatured and lose its functionality. Therefore, alterations in temperature and pH can impact enzyme activity by directly affecting their shapes. Choices A, C, and D are incorrect because while pH can affect acidity and chemical properties of the enzyme, and temperature can influence the enzyme-substrate interaction, the primary reason for enzyme activity alteration due to temperature and pH is the change in the enzyme's shape.

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