HESI A2
Biology HESI A2 2024
1. During which phase of cell division do the chromosomes replicate?
- A. Prophase
- B. Interphase
- C. Anaphase
- D. Telophase
Correct answer: B
Rationale: Chromosomes replicate during the interphase of the cell cycle. Interphase is the phase where the cell prepares for division by undergoing various activities such as growth, DNA replication, and protein synthesis. During DNA replication in interphase, each chromosome in the cell is duplicated to form two sister chromatids, which are then separated during cell division. Prophase is the phase where the chromosomes condense, and the nuclear envelope breaks down. Anaphase is the phase where sister chromatids are pulled apart towards opposite poles of the cell. Telophase is the phase where the nuclear envelope reforms, and chromosomes begin to decondense.
2. Which cells in the human body lack nuclei?
- A. Nerve cells
- B. Red blood cells
- C. Liver cells
- D. Connective tissue cells
Correct answer: B
Rationale: Red blood cells, also known as erythrocytes, lack nuclei in humans. This absence of a nucleus allows more space for hemoglobin, the protein responsible for carrying oxygen, making red blood cells efficient at their function of oxygen transport in the body. Nerve cells (Choice A), liver cells (Choice C), and connective tissue cells (Choice D) all possess nuclei as they require genetic material for their functions, such as cell signaling, protein synthesis, and structural support.
3. How many chromosomes do sperm and egg produce in meiosis?
- A. 23
- B. 46
- C. 25
- D. 50
Correct answer: A
Rationale: During meiosis, sperm and egg cells produce half the number of chromosomes found in somatic cells. Each contributes 23 chromosomes, which combine to form a zygote with a total of 46 chromosomes. Choice B (46) is incorrect because this is the number of chromosomes produced in mitosis, not meiosis. Choices C (25) and D (50) are also incorrect as they do not align with the chromosome count in sex cells during meiosis.
4. A scientist needs 12 mL of a solution. They have a bottle with 12L in it. Do they have enough?
- A. Yes, they have exactly what they need
- B. Yes, they have more than what they need
- C. No, they do not have enough
- D. None of the above
Correct answer: B
Rationale: 1 liter has 1000 milliliters. To convert from milliliters to liters, the decimal point moves three places to the left. So, the bottle has 12000 mL of solution, which is a lot more than the required 12 mL. Therefore, the scientist has more than what they need. Choice A is incorrect as the bottle has more than the required amount. Choice C is incorrect as the bottle contains significantly more solution than needed. Choice D is incorrect as the scientist does have more than enough solution.
5. During which phase of mitosis does the nuclear envelope disintegrate?
- A. Prophase
- B. Prophase
- C. Prometaphase
- D. Metaphase
Correct answer: C
Rationale: During the prometaphase stage of mitosis, the nuclear envelope disintegrates. This allows the condensed chromosomes to move towards the center of the cell, preparing for their alignment along the metaphase plate. The breakdown of the nuclear envelope is a crucial step in mitosis to ensure the proper segregation of genetic material into daughter cells. Choices A, B, and D are incorrect as the nuclear envelope disintegration specifically occurs during the prometaphase stage, not in prophase or metaphase.
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