HESI A2
Biology HESI A2 2024
1. Imagine that two parents both carry the recessive gene for cystic fibrosis. Any homozygous recessive offspring will manifest the disease. What percentage of the offspring is predicted to be carriers but not manifest the disease?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: When both parents carry the recessive gene for cystic fibrosis (homozygous recessive), there is a 25% chance for each offspring to inherit two recessive alleles and, therefore, manifest the disease. There is also a 50% chance for each offspring to inherit one recessive allele and one dominant allele, making them carriers of the disease but not manifest it. Therefore, 25% of the offspring are predicted to be carriers but not manifest the disease. Choice A (0%) is incorrect because there is a portion of offspring that will be carriers. Choice C (50%) is incorrect as this percentage corresponds to carriers who will not manifest the disease. Choice D (100%) is incorrect as not all offspring will be carriers and not manifest the disease.
2. When the genotype consists of a dominant and a recessive allele, the phenotype will be like the _ allele.
- A. Dominant
- B. Recessive
- C. Both
- D. Neither
Correct answer: A
Rationale: When the genotype consists of a dominant and a recessive allele, the phenotype will be like the dominant allele. This is because dominant alleles typically mask the expression of recessive alleles. Therefore, the dominant allele will be expressed in the phenotype in most basic cases. The recessive allele will only be expressed phenotypically if the individual is homozygous recessive. Choice B, 'Recessive,' is incorrect because the phenotype will not be like the recessive allele in this case. Choice C, 'Both,' is incorrect because in simple dominant-recessive inheritance, the dominant allele will overshadow the recessive allele. Choice D, 'Neither,' is incorrect as the phenotype will resemble the dominant allele.
3. Which of the following are considered the most important molecules in biology?
- A. Carbohydrates, lipids, protein, and nucleic acids
- B. Carbohydrates, lipids, protein, and calcium
- C. Carbohydrates, lipids, protein, and sulfur
- D. Carbohydrates, lipids, protein, and iron
Correct answer: A
Rationale: The correct answer is A: Carbohydrates, lipids, protein, and nucleic acids are considered the most important molecules in biology. Carbohydrates are essential for providing energy, lipids for storing energy and forming cell membranes, proteins for various structural and functional roles, and nucleic acids (DNA and RNA) for storing genetic information. Choices B, C, and D are incorrect because while carbohydrates, lipids, and proteins are crucial biomolecules, calcium, sulfur, and iron are not considered among the most important molecules in biology.
4. Which animal has an open transport system?
- A. Grasshopper
- B. Earthworm
- C. Dolphin
- D. Chicken
Correct answer: B
Rationale: The correct answer is B: Earthworm. Earthworms have an open circulatory system, meaning their blood and interstitial fluid are not enclosed in blood vessels. Instead, the blood flows freely within the body cavity, allowing for direct exchange of nutrients and waste products with surrounding tissues. This lack of a closed transport system is a characteristic feature of earthworms. Choices A, C, and D are incorrect because grasshoppers, dolphins, and chickens have closed circulatory systems where the blood is enclosed within blood vessels, unlike earthworms.
5. What propels the cell forward?
- A. Microfilaments
- B. Propulsion
- C. Cilia
- D. Flagella
Correct answer: B
Rationale: Propulsion, not microfilaments, cilia, or flagella, is what drives the cell forward. Propulsion is the force or process that propels the cell forward and allows it to move within its environment. Microfilaments are involved in cell structure, cilia are small hair-like structures for movement, and flagella are tail-like structures used for cell propulsion in some organisms.
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