HESI A2
Biology HESI A2 Practice Exam
1. Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. In an example of an unaffected father and a female carrier who have two daughters and two sons, which is the predicted outcome?
- A. Both daughters will carry the disease.
- B. Both sons will carry the disease.
- C. One daughter may have the disease.
- D. One son may have the disease.
Correct answer: C
Rationale: Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. Since the father is unaffected and does not carry the disease, he must have a normal X chromosome. The mother is a carrier, which means she has one normal X chromosome and one X chromosome with the disease allele. The daughters will inherit one X chromosome from each parent; one would be normal, and the other has a chance of carrying the disease allele. So, there is a 50% chance that one daughter may have the disease, as she could inherit the X chromosome with the disease allele. The sons will inherit the Y chromosome from the father and the X chromosome from the mother, so they will not be affected by the disease. Therefore, the predicted outcome is that one daughter may have the disease, while the sons will not carry the disease. This rules out choices A, B, and D.
2. When the genotype consists of a dominant and a recessive allele, the phenotype will be like the _ allele.
- A. Dominant
- B. Recessive
- C. Both
- D. Neither
Correct answer: A
Rationale: When the genotype consists of a dominant and a recessive allele, the phenotype will be like the dominant allele. This is because dominant alleles typically mask the expression of recessive alleles. Therefore, the dominant allele will be expressed in the phenotype in most basic cases. The recessive allele will only be expressed phenotypically if the individual is homozygous recessive. Choice B, 'Recessive,' is incorrect because the phenotype will not be like the recessive allele in this case. Choice C, 'Both,' is incorrect because in simple dominant-recessive inheritance, the dominant allele will overshadow the recessive allele. Choice D, 'Neither,' is incorrect as the phenotype will resemble the dominant allele.
3. A cell from heart muscle would more than likely contain an unusually high proportion of which of the following?
- A. lysosomes
- B. mitochondria
- C. mRNA
- D. ribosomes
Correct answer: B
Rationale: A cell from heart muscle would more than likely contain an unusually high proportion of mitochondria because the heart muscle requires a significant amount of energy to function properly. Mitochondria are the powerhouse of the cell and are responsible for producing energy in the form of ATP through cellular respiration. Therefore, to meet the high energy demands of the heart muscle, it would need a higher concentration of mitochondria compared to other cell types. Choices A, C, and D are incorrect because while lysosomes, mRNA, and ribosomes are essential components of a cell, they do not play as direct a role in meeting the high energy demands of heart muscle as mitochondria do.
4. What organelle is responsible for packaging, processing, and shipping?
- A. Nucleus
- B. Golgi Apparatus
- C. Endoplasmic Reticulum
- D. Ribosomes
Correct answer: B
Rationale: The Golgi Apparatus is the correct answer. It is responsible for packaging, processing, and shipping proteins and lipids within the cell. The nucleus houses genetic material, the endoplasmic reticulum is involved in protein synthesis and lipid metabolism, and ribosomes are responsible for protein synthesis. Therefore, choices A, C, and D are not the correct answers for the functions of packaging, processing, and shipping.
5. Which component of the cell contributes to the protection, communication, and passage of substances into and out of the cell?
- A. Nucleus
- B. Cell membrane
- C. Endoplasmic reticulum
- D. Cytoplasm
Correct answer: B
Rationale: The correct answer is the cell membrane. The cell membrane is responsible for protecting the cell, facilitating communication with the external environment, and regulating the passage of substances into and out of the cell. The nucleus (Choice A) is the control center of the cell and houses the genetic material but is not primarily involved in these functions. The endoplasmic reticulum (Choice C) is involved in protein synthesis and lipid metabolism, not primarily in protection or communication. The cytoplasm (Choice D) is the gel-like substance that fills the cell but does not specifically contribute to protection, communication, or substance passage.
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