HESI A2
HESI A2 Practice Test Biology
1. Which organelle contains the genetic material of the cell?
- A. Golgi apparatus
- B. Ribosome
- C. Endoplasmic reticulum
- D. Nucleus
Correct answer: D
Rationale: The correct answer is 'D: Nucleus.' The nucleus is the organelle that contains the cell's genetic material, which is the DNA. The genetic material in the nucleus controls the cell's activities and plays a crucial role in inheritance. Choices A, B, and C are incorrect because the Golgi apparatus is involved in modifying, sorting, and packaging of proteins; ribosomes are involved in protein synthesis; and endoplasmic reticulum is involved in protein and lipid synthesis and transportation, but none of them contain the genetic material of the cell.
2. Huntington’s disease is carried on the dominant allele. In a situation where two heterozygous parents have the disease, what percentage of their offspring are predicted to be disease-free?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: In this scenario, both parents are heterozygous for Huntington's disease, meaning each carries one dominant allele (representing the disease) and one recessive allele (representing no disease). When they have offspring, there is a 25% chance that each child will inherit two recessive alleles, making them disease-free. The Punnett square for two heterozygous parents (Hh x Hh) yields a 25% probability of offspring being homozygous recessive (hh) and therefore disease-free. Choice A (0%) is incorrect because there is a possibility of disease-free offspring. Choice C (50%) is incorrect as it represents the likelihood of being a carrier. Choice D (100%) is incorrect as all offspring will not be disease-free in this scenario.
3. Imagine that two parents both carry the recessive gene for cystic fibrosis. Any homozygous recessive offspring will manifest the disease. What percentage of the offspring is predicted to be carriers but not manifest the disease?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: When both parents carry the recessive gene for cystic fibrosis (homozygous recessive), there is a 25% chance for each offspring to inherit two recessive alleles and, therefore, manifest the disease. There is also a 50% chance for each offspring to inherit one recessive allele and one dominant allele, making them carriers of the disease but not manifest it. Therefore, 25% of the offspring are predicted to be carriers but not manifest the disease. Choice A (0%) is incorrect because there is a portion of offspring that will be carriers. Choice C (50%) is incorrect as this percentage corresponds to carriers who will not manifest the disease. Choice D (100%) is incorrect as not all offspring will be carriers and not manifest the disease.
4. Why does cytokinesis happen?
- A. DNA can duplicate
- B. Organelles can convert energy
- C. Bacteria can be killed
- D. Daughter cells can divide
Correct answer: D
Rationale: Cytokinesis happens at the end of mitosis to physically separate the newly formed daughter cells. This allows the cell to divide into two separate daughter cells, each containing a complete set of genetic material (DNA) and organelles. The purpose of cytokinesis is to ensure that each daughter cell receives the necessary components to function independently. Choices A, B, and C are incorrect because cytokinesis does not directly involve DNA duplication, organelles converting energy, or killing bacteria.
5. Which of the following is false?
- A. Animal cells use lysosomes to break down old cells
- B. Animal cells use chloroplasts to gain energy
- C. Plant cells have a cell wall to maintain structure
- D. All of the above are true
Correct answer: B
Rationale: The statement "B. Animal cells use chloroplasts to gain energy" is false. Chloroplasts are only present in plant cells and certain algae, where they are responsible for photosynthesis to generate energy from sunlight. Animal cells rely on other organelles, such as mitochondria, for energy production. Choice A is true because animal cells use lysosomes to break down old cells and cellular waste. Choice C is true as plant cells have a cell wall composed of cellulose that provides structural support and protection.
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