HESI A2
Biology HESI A2 2024
1. How should a researcher test the hypothesis that eating chocolate leads to acne in teenagers?
- A. Take 100 teenagers and feed each one a different amount of chocolate daily for 60 days; then test for acne.
- B. Take 100 teenagers and feed 50 two bars of chocolate daily for 60 days while the other 50 eat no chocolate; then test for acne.
- C. Take 1 teenager and feed him or her two bars of chocolate for 30 days and no chocolate for 30 days; then test for acne.
- D. Take 100 teenagers and feed them no chocolate for 30 days and two bars of chocolate apiece for 30 days; then test for acne.
Correct answer: B
Rationale: Option B is the correct approach to test the hypothesis that eating chocolate leads to acne in teenagers. This method involves having a control group (50 teenagers not consuming chocolate) and an experimental group (50 teenagers consuming two bars of chocolate daily), which allows for comparison. By having two distinct groups, researchers can assess the impact of chocolate consumption on acne development. Option A lacks a control group for comparison, making it harder to attribute any observed effects specifically to chocolate consumption. Option C only involves a single subject, which limits the generalizability of the results. Option D, where all teenagers experience both conditions, does not allow for a direct comparison between chocolate consumption and acne development, as all subjects are exposed to both conditions.
2. Tonicity refers to the movement of:
- A. Water
- B. Solute
- C. Cells
- D. None of the above
Correct answer: A
Rationale: Tonicity refers to the movement of water across a membrane in response to differences in solute concentration. In a hypertonic solution, where there is a higher concentration of solutes outside the cell, water will move out of the cell to try to reach equilibrium. In a hypotonic solution, where there is a lower concentration of solutes outside the cell, water will move into the cell to balance the concentrations. Cells and solutes themselves do not actively move in response to tonicity; it is the movement of water that helps achieve equilibrium. Therefore, the correct answer is water (Choice A). Choices B, C, and D are incorrect as tonicity specifically refers to water movement and not the movement of solutes, cells, or none of the above.
3. In which phase of mitosis do new nuclear membranes form around sets of chromosomes?
- A. Prophase
- B. Anaphase
- C. Telophase
- D. Interphase
Correct answer: C
Rationale: The correct answer is C, Telophase. During telophase, the final phase of mitosis, new nuclear membranes form around sets of chromosomes at the opposite poles of the cell. This process marks the completion of nuclear division in mitosis. Choices A, B, and D are incorrect because in prophase, chromosomes condense but nuclear membranes are not formed; in anaphase, chromosomes separate and move to opposite poles but no new nuclear membranes are formed; and in interphase, the cell prepares for division but nuclear membranes are not forming around sets of chromosomes.
4. The two catabolic pathways that lead to cellular energy production are:
- A. fermentation and protein synthesis
- B. cellular respiration and glycolysis
- C. fermentation and glycolysis
- D. cellular respiration and fermentation
Correct answer: D
Rationale: The correct answer is D: cellular respiration and fermentation. Cellular respiration involves the breakdown of glucose in the presence of oxygen to produce ATP, which is the primary source of energy for cells. Fermentation, on the other hand, occurs in the absence of oxygen and produces ATP through glycolysis followed by specific fermentation pathways. Choices A, B, and C are incorrect. Protein synthesis is a biosynthetic process, not a catabolic pathway for energy production. Glycolysis is a common step in both cellular respiration and fermentation, so it is not a pair of distinct catabolic pathways. Therefore, the most accurate pairing of catabolic pathways for cellular energy production is cellular respiration and fermentation.
5. Which of the following structures is not directly involved in translation?
- A. tRNA
- B. mRNA
- C. ribosome
- D. DNA
Correct answer: D
Rationale: The correct answer is 'D: DNA.' DNA is not directly involved in translation, which is the process of synthesizing proteins from mRNA. tRNA carries amino acids to the ribosome, mRNA provides the template for protein synthesis, and ribosomes are the cellular machinery where translation occurs. DNA's main role is in transcription, where it serves as the template for mRNA synthesis, not in translation.
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