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1. Which of the following statements is a characteristic of supermales?
- A. They are somewhat taller than average.
- B. Their facial hair growth is minimal when compared to normal males.
- C. They suffer from gynecomastia.
- D. They are typically impotent.
Correct answer: A
Rationale: The correct characteristic of supermales, individuals with an XYY chromosome pattern, is that they are somewhat taller than average. Choice B is incorrect as supermales do not exhibit minimal facial hair growth compared to normal males. Choice C is incorrect as gynecomastia, the development of male breasts, is not a characteristic of supermales. Choice D is also incorrect as impotence is not a typical characteristic associated with supermales.
2. Which of the following statements is true of Down’s syndrome?
- A. Down’s syndrome is usually caused by an extra copy of chromosome 21 in an individual.
- B. The symptoms of Down’s syndrome are similar to those of sickle-cell anemia.
- C. Down’s syndrome is caused by a sexually transmitted infection (STI) during conception.
- D. The probability of having a child with Down’s syndrome increases with the age of the parents.
Correct answer: D
Rationale: The correct answer is D. The likelihood of having a child with Down’s syndrome increases as the age of the parents increases, particularly the mother's age. Choice A is incorrect because Down’s syndrome is caused by an extra copy of chromosome 21, not a defect in the sex chromosomes. Choice B is incorrect as the symptoms of Down’s syndrome and sickle-cell anemia are different. Choice C is also incorrect as Down’s syndrome is not caused by a sexually transmitted infection during conception.
3. Which of the following statements is a symptom of cystic fibrosis in children?
- A. Cystic fibrosis leads to uncontrollable muscle movements and personality changes.
- B. Cystic fibrosis leads to the excessive production of thick mucus that clogs the pancreas and lungs.
- C. Cystic fibrosis causes red blood cells to clump together, obstructing small blood vessels and decreasing the oxygen supply.
- D. Cystic fibrosis causes the central nervous system to degenerate, resulting in death.
Correct answer: B
Rationale: The correct answer is B. Cystic fibrosis is a genetic disorder that causes the body to produce thick, sticky mucus. This mucus can clog the airways in the lungs and obstruct the pancreas, leading to severe respiratory and digestive problems. Choice A is incorrect because uncontrollable muscle movements and personality changes are not typical symptoms of cystic fibrosis. Choice C is incorrect because cystic fibrosis does not directly cause red blood cells to clump together and obstruct small blood vessels. Choice D is incorrect because cystic fibrosis primarily affects the respiratory and digestive systems, not the central nervous system.
4. Thalidomide was marketed in the 1960s as a treatment for:
- A. insomnia and nausea.
- B. infertility and impotence.
- C. Down syndrome.
- D. Turner syndrome.
Correct answer: A
Rationale: Thalidomide was initially marketed as a treatment for insomnia and nausea, particularly in pregnant women. However, it was later found to cause severe birth defects, leading to significant consequences. Choice B, infertility and impotence, is incorrect as thalidomide was not marketed for these conditions. Choices C and D, Down syndrome and Turner syndrome, are genetic conditions and not conditions for which thalidomide was intended as a treatment.
5. Which of the following is a fatal genetic neurologic disorder whose onset is in middle age?
- A. Tay-Sachs disease
- B. Duchenne muscular dystrophy
- C. Hemophilia
- D. Huntington’s disease
Correct answer: D
Rationale: Huntington's disease is a fatal genetic neurologic disorder characterized by progressive nerve cell degeneration in the brain. It typically manifests in middle age with symptoms such as involuntary movements, cognitive decline, and psychiatric disturbances. Tay-Sachs disease (Choice A) is a genetic disorder that primarily affects the nervous system in early childhood, not middle age. Duchenne muscular dystrophy (Choice B) is a genetic disorder that primarily affects muscle function and usually presents in early childhood. Hemophilia (Choice C) is a genetic disorder related to blood clotting, and its onset is not typically in middle age.
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