Nursing Elites

1. Which of the following statements regarding macrophages is incorrect?

• A. They are found abundantly in the blood
• B. They are larger than neutrophils
• C. They are long-lived
• D. They are made in the bone marrow as monocytes, called macrophages once they reach organs

Correct answer: A

Rationale: The correct answer is A. Macrophages are not found abundantly in the blood; they are present in tissues and organs. Macrophages are tissue-resident immune cells that play a key role in immune responses and are derived from monocytes produced in the bone marrow. Choice B is correct as macrophages are larger than neutrophils. Choice C is correct as macrophages are long-lived cells. Choice D is correct as macrophages originate in the bone marrow as monocytes and differentiate into macrophages once they migrate to various tissues and organs.

2. Microfilaments and microtubules are both components of the cytoskeleton, but they have different functions. Which of these describes microfilaments?

• A. Provide structural support and shape
• B. Facilitate cell movement and contraction
• C. Form the mitotic spindle during cell division
• D. Transport materials within the cell

Correct answer: A

Rationale: Microfilaments are thin, solid rods made of the protein actin and are primarily responsible for providing structural support to the cell and determining its shape. While they also play a role in cell movement, their main function is related to maintaining the structural integrity of the cell. Choice B, 'Facilitate cell movement and contraction,' describes microtubules, which are responsible for facilitating cell movement, providing structural support, and aiding in cell division. Choice C, 'Form the mitotic spindle during cell division,' specifically refers to the function of microtubules in forming the mitotic spindle. Choice D, 'Transport materials within the cell,' is characteristic of microtubules that are involved in intracellular transport of organelles and materials within the cell.

3. What type of inheritance pattern results in a 3:1 ratio of dominant to recessive phenotypes in the F2 generation?

• A. Incomplete dominance
• B. Codominance
• C. Sex-linked inheritance
• D. Autosomal dominant inheritance

Correct answer: D

Rationale: Autosomal dominant inheritance results in a 3:1 ratio of dominant to recessive phenotypes in the F2 generation. This inheritance pattern occurs when a single copy of the dominant allele is enough to express the dominant phenotype. A) Incomplete dominance: In incomplete dominance, the heterozygous phenotype is a blend of the two homozygous phenotypes, and it does not lead to a 3:1 ratio of dominant to recessive phenotypes in the F2 generation. B) Codominance: In codominance, both alleles are fully expressed in the heterozygous phenotype, but this pattern also does not result in a 3:1 ratio of dominant to recessive phenotypes in the F2 generation. C) Sex-linked inheritance: Sex-linked inheritance involves genes located on the sex chromosomes and does not typically lead to a 3:1 ratio of dominant to recessive phenotypes in the F2 generation.

4. Which type of nuclear reaction releases a large amount of energy in a short time?

• A. Radioactivity
• B. Nuclear fission
• C. Nuclear fusion
• D. All of the above

Correct answer: C

Rationale: Nuclear fusion releases a large amount of energy in a short time by combining two light atomic nuclei to form a heavier nucleus. This process is the energy source of the sun and hydrogen bombs. Radioactivity involves the spontaneous emission of particles or energy from an unstable atomic nucleus, while nuclear fission is the splitting of a heavy atomic nucleus into two or more lighter nuclei, also releasing energy. While all the options are types of nuclear reactions, nuclear fusion is specifically known for releasing a large amount of energy rapidly, making it the correct choice in this context. Choices A and B are incorrect as they do not specifically describe the process of releasing a large amount of energy in a short time. Choice D is incorrect because not all the options listed release a large amount of energy in a short time, making it an inaccurate answer.

5. What is the significance of studying pedigrees in human genetics?

• A. Predicting the exact outcome of genetic crosses in humans.
• B. Tracing the inheritance of complex traits with multiple contributing genes.
• C. Identifying carriers of dominant genetic disorders.
• D. Determining the risk of acquiring a specific mutation de novo.

Correct answer: B

Rationale: Pedigrees are diagrams that show the relationships within a family and can be used to track the inheritance patterns of specific traits or diseases. While pedigrees can provide information on the inheritance of single gene disorders (such as identifying carriers of dominant genetic disorders, as mentioned in option C), their primary significance lies in studying complex traits with multiple contributing genes. These traits do not follow simple Mendelian inheritance patterns and are influenced by both genetic and environmental factors. By analyzing pedigrees, researchers can identify patterns of inheritance for complex traits, such as polygenic diseases or traits influenced by gene-environment interactions. Therefore, option B is the most appropriate choice as it captures the main significance of studying pedigrees in human genetics.

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