Nursing Elites

1. What is the most common cause of aseptic meningitis?

• A. Bacteria
• B. Viruses
• C. Fungi
• D. Parasites

Correct answer: B

Rationale: Aseptic meningitis is typically caused by viral infections, such as enteroviruses (e.g., coxsackievirus, echovirus), herpes simplex virus, varicella-zoster virus, and others. These viruses can infect the meninges, leading to inflammation and symptoms of meningitis without the presence of bacteria. While bacterial meningitis is a serious and life-threatening condition, aseptic meningitis caused by viruses is usually less severe and has a better prognosis. Fungi and parasites are less common causes of meningitis compared to bacteria and viruses.

2. What is the stage of mitosis during which the nuclear envelope reforms?

• A. Prophase
• B. Metaphase
• C. Telophase
• D. Cytokinesis

Correct answer: C

Rationale: During telophase, the nuclear envelope reforms around the separated sister chromatids at opposite poles of the cell. This stage marks the reversal of the processes that occurred during prophase, where the nuclear envelope breaks down. Metaphase is characterized by the alignment of chromosomes along the metaphase plate in the cell's center. Cytokinesis is the final step of cell division involving cytoplasmic division to form two daughter cells, but it does not involve the reformation of the nuclear envelope. Therefore, choice C (Telophase) is the correct answer as it specifically involves the reformation of the nuclear envelope, distinguishing it from the other stages of mitosis.

3. Where does visual processing begin in the eye?

• A. Cornea
• B. Optic nerve
• C. Retina
• D. Eyelid

Correct answer: C

Rationale: Visual processing begins in the retina, not the cornea, optic nerve, or eyelid. The retina is a layer of tissue at the back of the eye that contains photoreceptor cells responsible for converting light into neural signals that are then sent to the brain for processing. The cornea is the transparent outer layer of the eye that helps focus light, but it does not process visual information. The optic nerve transmits visual information from the retina to the brain, it does not initiate visual processing. The eyelid is a protective covering for the eye and is not involved in visual processing.

4. How do spindle fiber dynamics and microtubule attachment regulate cell cycle checkpoints?

• A. Misaligned chromosomes fail to attach to microtubules, triggering a delay in anaphase onset.
• B. The presence of unattached kinetochores on the centromeres sends a signal to pause cell cycle progression.
• C. Microtubule instability and rapid depolymerization lead to the activation of checkpoint proteins.
• D. All of the above.

Correct answer: D

Rationale: A) Misaligned chromosomes fail to attach to microtubules, triggering a delay in anaphase onset: Proper attachment of chromosomes to spindle fibers is essential for accurate segregation of genetic material during cell division. Misaligned chromosomes that fail to attach to microtubules can lead to delays in anaphase onset, allowing the cell to correct errors before proceeding with division. B) The presence of unattached kinetochores on the centromeres sends a signal to pause cell cycle progression: Kinetochores at the centromeres help attach chromosomes to spindle fibers. When kinetochores are unattached or improperly attached to microtubules, they signal the cell to pause cell cycle progression, ensuring proper chromosome alignment before division. C) Microtubule instability and rapid depolymerization lead to the activation of checkpoint proteins: While microtubule dynamics are crucial for cell division, microtubule instability and rapid depolymerization can disrupt chromosome attachment. However, this mechanism is not directly related to the activation of cell cycle checkpoint proteins, making this statement incorrect. Therefore, choices A and B accurately describe how spindle fiber dynamics and microtubule attachment regulate cell cycle checkpoints, making option D the correct answer.

5. What is the significance of studying pedigrees in human genetics?

• A. Predicting the exact outcome of genetic crosses in humans.
• B. Tracing the inheritance of complex traits with multiple contributing genes.
• C. Identifying carriers of dominant genetic disorders.
• D. Determining the risk of acquiring a specific mutation de novo.

Correct answer: B

Rationale: Pedigrees are diagrams that show the relationships within a family and can be used to track the inheritance patterns of specific traits or diseases. While pedigrees can provide information on the inheritance of single gene disorders (such as identifying carriers of dominant genetic disorders, as mentioned in option C), their primary significance lies in studying complex traits with multiple contributing genes. These traits do not follow simple Mendelian inheritance patterns and are influenced by both genetic and environmental factors. By analyzing pedigrees, researchers can identify patterns of inheritance for complex traits, such as polygenic diseases or traits influenced by gene-environment interactions. Therefore, option B is the most appropriate choice as it captures the main significance of studying pedigrees in human genetics.

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